Influence of Dapagliflozin on glucose metabolism and cardiac function in elderly patients with ST-segment elevation myocardial infarction complicated with type 2 diabetes mellitus after percutaneous coronary intervention
10.3969/j.issn.1006-6187.2025.08.004
- VernacularTitle:达格列净改善老年ST段抬高型心肌梗死合并2型糖尿病患者经皮冠状动脉介入术后心功能及糖代谢的研究
- Author:
Yuli LU
1
;
Jiandong XIAO
;
Ya WANG
Author Information
1. 053000 衡水市人民医院内分泌科
- Publication Type:Journal Article
- Keywords:
ST segment elevation myocardial infarction;
Diabetes mellitus,type 2;
Elderly;
Dapagliflozin
- From:
Chinese Journal of Diabetes
2025;33(8):577-581
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the influence of Dapagliflozin on ventricular remodeling,soluble suppression of tumorigenicity-2(sST2)and brain natriuretic peptide(BNP)in patients with elderly ST-segment elevation myocardial infarction(STEMI)complicated with type 2 diabetes mellitus(T2DM)after percutaneous coronary intervention(PCI).Methods From April 2021 to March 2023,118 elderly patients with STEMI complicated with T2DM treated by PCI were selected from People's Hospital of Hengshui.They were divided into conventional hypoglycemic therapy control(Con,n=59)group and conventional hypoglycemic therapy combined with Dapagliflozin(Dap,n=59)group according to the treatment strategy.All the participants were treated for 24 weeks.The general data,biochemical indexes,BNP,N-terminal pro-B-type natriuretic peptide(NT-proBNP),soluble growth stimulating expression factor 2(sST2)and lipoprotein-associated phospholipase A2(LP-PLA2),left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),and left ventricular mass index(LVMI)were compared between the two groups.Results After 24 weeks of treatment,the BNP,NT-proBNP,fasting plasma glucose(FPG),2 h postprandial blood glucose(2 hPG),glycosylated hemoglobin(HbA1c),LVEDD,LVESD,LVMI,serum sST2 and LP-PLA2 were lower in Dap group than in Con group(P<0.05),while the LVEF was higher in Dap group than in Con group(P<0.05).The total incidence rate of major adverse cardiovascular events was significantly lower in Dap group than in Con group(P<0.05).The incidence rates of adverse drug reactions were 6.78%and 5.08%in the two groups respectively(P>0.05).Conclusions Dapagliflozin can improve the cardiac function and glucose metabolism status in elderly patients with STEMI and T2DM after PCI,and alleviate the ventricular remodeling,with good safety.
