Effect of CSMD1 polymorphism on grey matter volume and category fluency in patients with schizophrenia
10.3760/cma.j.issn.1006-7884.2017.04.010
- VernacularTitle:CSMD1基因多态性与精神分裂症患者词语流畅性及脑灰质体积的关联研究
- Author:
Jing LI
1
;
Hao YU
1
;
Jinmin LIAO
1
;
Sisi JIANG
1
;
Qi LIU
1
;
Jun YAN
1
;
Weihua YUE
1
;
Hao YAN
1
;
Dai ZHANG
1
Author Information
1. 100191,北京大学第六医院北京大学精神卫生研究所卫生部精神卫生学重点实验室(北京大学)国家精神心理疾病临床医学研究中心(北京大学第六医院
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Polymorphism;
single nucleotide;
Cognition;
CUB and Sushi multiple domains1;
Grey matter volume
- From:
Chinese Journal of Psychiatry
2017;50(4):282-288
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of single nucleotide polymorphisms in CSMD1 on grey matter volume(GMV)and verbal fluency in schizophrenic patients. Methods Eighty-seven schizophrenic patients and 98 normal controls underwent MRI scanning, cognitive assessment and whole-genome genotyping. Linear regression model was conducted to explore the association between the genotype of CSMD1 and cognitive function (digit symbol substitution test(DSST),verbal fluency test(VFT)); The full factorial analysis was conducted to explore the effect of CSMD1 gene and diagnosis and diagnosis × gene interaction on GMV,then did the post hoc analysis and explored the association between cognition and the GMV of diagnosis×gene interaction. Results The performance scores of DSST(t=-7.51,P<0.05)and VFT (t=-3.23,P<0.05)were significantly reduced in patients. A significant association was observed between the polymorphisms of CSMD1 rs17405197 and the VFT performance scores in patients. The full factorial analysis showed that GMV in left rectal gyrus and bilateral superior temporal lobe had significant main effect of diagnosis;the post hoc analysis showed that compared with the healthy control,the GMV in the above regions was significantly reduced in patients. The main effect of CSMD1 rs17405197 genotype was found in the pars triangularis of right inferior frontal gyrus (MNI(x,y,z):54,27,9,F=35.75,FWE correction,P<0.05,k>10);the post hoc analysis showed that compared with the CSMD1 rs17405197 AC+CC carriers,the GMV in the above regions significantly decreased in subjects with AA genotype. The interaction effect between the diagnosis and genotype was found in the pars opercularis of right inferior frontal gyrus (MNI (x,y,z):51,20,15,F=20.55,P<0.001 uncorrected,k>100). The partial correlation analysis showed that only in the patient group,the GMV in the pars opercularis of right inferior frontal gyrus was negatively correlated with VFT score(r=-0.28,P=0.01). Conclusion The effect of GSMD1 rs17405197 polymorphism on the pars opercularis of right inferior frontal gyrus in patients with schizophrenia might underly the neuropathological bases of their VFT impairment.
