Role of senescent cells in bone-related diseases:An updated review

VernacularTitle:衰老细胞和骨相关疾病关系的研究进展
Author: Jinru TANG ¹ ; Bo LI ; Yunkun LIU ; Zeyu HOU ; Longjiang LI
Author Information

1. 口腔疾病防治全国重点实验室,国家口腔医学中心,国家口腔疾病临床医学研究中心,四川大学华西口腔医院头颈肿瘤外科,四川成都(610041)
Publication Type:Journal Article
Keywords: senescent cells; senescence-associated secretory phenotype; bone diseases
From: STOMATOLOGY 2025;45(2):134-138,145
CountryChina
Language:Chinese
Abstract: Bone-related diseases are a group of inflammatory diseases characterized by abnormal bone resorption and formation,with a wide variety of diseases involving age,inflammation,obesity,genetics,radiation,and other pathogenic factors.In recent years,se-nescent cells have become an important mechanism for age-related diseases,and their role in bone-related diseases has attracted the at-tention of researchers.Senescent cells are gradually being used as therapeutic targets for bone-related diseases.In this paper,we pres-ent a review of the mechanism of senescent cells in various types of bone-related diseases,which will provide new strategies for the pre-vention and treatment of bone diseases.