Research Progress on Cytokine Release Syndrome Induced by CAR-T Therapy and Pharmacological Treatment
10.3870/j.issn.1004-0781.2025.07.018
- VernacularTitle:CAR-T疗法诱发的细胞因子释放综合征及药物治疗研究进展
- Author:
Yi HE
1
;
Lei ZHU
1
Author Information
1. 中国医学科学院基础医学研究所,北京协和医学院基础学院药理系,北京 100005
- Publication Type:Journal Article
- Keywords:
Chimeric antigen receptor T cells;
Cytokine release syndrome;
Cytokine storm;
Immunotherapy
- From:
Herald of Medicine
2025;44(7):1116-1125
- CountryChina
- Language:Chinese
-
Abstract:
Chimeric antigen receptor T cell(CAR-T)therapy has emerged as a breakthrough treatment for various malignancies.However,its major adverse effect,cytokine release syndrome(CRS),remains a critical limitation to its widespread application.The pathophysiological mechanisms of CRS are complex,involving abnormal activation and interactions of multiple immune cells and cytokines,often leading to systemic inflammatory responses and multi-organ damage.In recent years,research on CRS mechanisms has deepened,uncovering key immune pathways involved in its pathogenesis and providing a foundation for developing novel intervention strategies.This article systematically reviews the concept of CRS,its pathological mechanisms,and the latest advances in therapeutic agents for prevention and treatment,aiming to provide a scientific basis for improving the safety of CAR-T therapies and optimizing clinical strategies for managing CRS.
