Origin Traceability Study of Artemisiae Argyi Folium Based on Elemental Fingerprint Combined with Chemometrics
10.3870/j.issn.1004-0781.2025.07.021
- VernacularTitle:基于元素指纹结合化学计量学的蕲艾产地溯源研究
- Author:
Yiqin FEI
1
;
Lihui ZHENG
;
Bo WANG
;
Ling XIAO
;
Pan LYU
;
Min HU
;
Shimei PENG
Author Information
1. 湖北省药品监督检验研究院/国家药品监督管理局中药质量控制重点实验室/湖北省药品质量检测与控制工程技术研究中心,武汉 430075
- Publication Type:Journal Article
- Keywords:
Artemisiae Argyi Folium;
Mineral elements fingerprint;
Chemometrics;
Identification of origin;
Traceability
- From:
Herald of Medicine
2025;44(7):1142-1149
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish an inductively coupled plasma-mass spectrometry(ICP-MS)method for the analysis of 29 mineral elements in Artemisiae Argyi Folium(AAF),and to develop a model for judging the origin of AAF based on the elemental fingerprint combined with chemometrics.Methods The variance method was used to compare the contents of 29 mineral elements in AAF samples from Qichun of Hubei province,Hebei province and Henan province,respectively.The discriminant models of AAF from different habitats were established by discriminant analysis,PLS-DA and PCA-Logistic regression algorithms.Results The differences of the 22 elements(V,Cr,Ni,As,Se,Rb,Mo,Cd,Sb,Ba,Hg,Pb,K,Li,B,Mg,Al,P,Ca,Fe,Zn,and Ga)in samples from Qichun of Hubei province,Hebei province and Henan province are extremely significant(P＜0.01).The discriminant analysis model showed that eight kinds of element variables(P,Cr,K,Li,Hg,Ba,Mg,and Mo),which have a significant effect on the origin discrimination are gradually introduced into the discriminant model,and the correct rate of back test is 100％.The correct rate of"leave one method"cross-validation is 96.7％.The PLS-DA model showed good prediction ability,and the variable importance projection values of K,P and Mg elements were greater than one,which could be used as the difference marker of AAF from different habitats.The accuracy of the origin discrimination model constructed by PC A-Logistic regression analysis was 100％.The elements with high first principal component loadings were Li,B,Mg,Al,P,K,Ca,V,Cr,Fe,Ni,Zn,As,Rb,Cd,Sb,and Ba.Conclusion This study shows that elemental fingerprint technology combined with chemometric analysis can identify AAF from Qichun of Hubei province,Hebei province,or Henan,providing technical support for the traceability of the origin of Artemisia argyi.
