Prediction of Multifunctional Parameters of SPECT Gated Myocardial Perfusion Imaging for Major Adverse Cardiovascular Events in Chronic Kidney Disease
10.3969/j.issn.1005-5185.2025.07.012
- VernacularTitle:SPECT门控心肌灌注显像多功能参数预测慢性肾脏病患者主要不良心血管事件的价值
- Author:
Ying ZHANG
1
;
Zhi CHANG
1
;
Xu HAN
1
;
Jian JIAO
1
;
Zihe YANG
1
;
Quan LI
1
;
Wei DONG
1
;
Hongzhi MI
1
Author Information
1. 首都医科大学附属北京安贞医院核医学科,北京 100029
- Publication Type:Journal Article
- Keywords:
Renal insufficiency,chronic;
Tomography,emission-computed,single-photon;
Myocardial perfusion imaging;
Forecasting;
Phase analysis;
Prognosis
- From:
Chinese Journal of Medical Imaging
2025;33(7):751-757
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To evaluate the predictive value of multifunctional parameters of single photon emission computed tomography gated myocardial perfusion imaging(SPECT G-MPI)for major adverse cardiovascular events(MACE)in chronic kidney disease(CKD)with abnormal stress myocardial perfusion.Materials and Methods A total of 99 patients diagnosed with CKD from June 2017 to March 2024 who underwent stress and rest G-MPI indicating abnormal myocardial perfusion in Beijing Anzhen Hospital,Capital Medical University.The American Heart Association 17-segment 5-point method and PHASE software were used to obtain the left ventricular myocardial perfusion,functional and synchronization parameters.According to the occurrence of MACE,the patients were divided into MACE group and non-MACE group.Cox regression was used to analyze the predictors related to MACE.The receiver operator characteristic curve was used to analyze the performance of predictors,the survival curves were obtained by the Kaplan-Meier method,Log-rank test was used to compare the differences in different groups.Results Finally,we enrolled 99 CKD patients with abnormal stress myocardial perfusion.35 patients(35.35%)developed MACE during the follow-up period.Cox regression analysis showed that stress phase bandwidth(SPBW)(HR=1.015,95%CI 1.002-1.028)and sum difference score(SDS)(HR=1.105,95%CI 1.008-1.211)were independent risk factors for predicting MACE(both P<0.05).The optimal cut-off value of SPBW and SDS for predicting MACE were 69° and 6 points,the area under the curve was 0.801 and 0.778,respectively.The incidence of MACE in the SPBW≥69° group and SDS≥6 points group was higher than that in SPBW<69° group and SDS<6 points group(66.6%vs.13.2%,53.3%vs.20.4%,both P<0.05).Conclusion SPECT G-MPI multifunctional parameters can be used to predict the prognosis of CKD patients with abnormal stress myocardial perfusion.SPBW and SDS are independent risk factors for MACE in these patients.
