Research progress on the mechanism of acquired resistance of Pseudomonas aeruginosa
10.3969/j.issn.1002-2694.2025.00.014
- VernacularTitle:铜绿假单胞菌获得性耐药机制研究进展
- Author:
Xiao-jing YANG
1
;
Dan YAN
1
;
Zhen-yu JIANG
1
;
Zhi-jun YU
1
;
Hai-ying DENG
1
Author Information
1. 武汉科技大学医学院新药创制研究所,职业危害识别与控制湖北省重点实验室,武汉 430065
- Publication Type:Journal Article
- Keywords:
Pseudomonas aeruginosa;
resistance mechanisms;
gene mutation;
horizontal gene transfer
- From:
Chinese Journal of Zoonoses
2025;41(1):85-93
- CountryChina
- Language:Chinese
-
Abstract:
Pseudomonas aeruginosa(PA)is an opportunistic pathogen commonly involved in environmental-and difffcult-to-treat nosocomial infection.Currently,multidrug-resistant(MDR)and extensively drug-resistant(XDR)strains of PA are e-merging due to the inappropriate use of antibiotics,which has become a major threat related to healthcare.The antibiotics re-sistance mechanism of PA is very complicated.PA can acquire resistance through mutations in genes encoding for membrane-associated proteins,antibiotics inactivation enzymes and their regulatory proteins,antibiotics target proteins,and two-compo-nent systems.Additionally,resistance genes acquired by horizontal gene transfer(HGT)lead to resistance of PA,which are frequently localized within mobile genetic elements(MGEs),including genes encoding enzymes that inactivate and modify anti-biotics,proteins genes that protect and modify antibiotic targets.In this review,acquired resistance mechanisms of PA involved in gene mutations and HGT was summarized.This review would provide references for the prevention and treatment of PA in-fection,as well as the research and development of new antibiotics.
