Pathogenetic analysis of the first case of ST-7962 group B meningococcal disease in Jiangxi Province
10.3969/j.issn.1002-2694.2025.00.009
- VernacularTitle:江西省首例ST-7962型B群流行性脑脊髓膜炎病例病原学分析
- Author:
Huan FANG
1
;
Yong LIAO
1
;
Xiao-jun HU
1
;
Qiong LEI
1
;
Xiao-rong ZHONG
1
;
Jue-xin WANG
1
;
Su-ping WANG
1
;
Man-mei TANG
1
;
Yu-chen WU
1
;
Chu-chu WU
1
Author Information
1. 赣州市疾病预防控制中心,贛州 341000
- Publication Type:Journal Article
- Keywords:
epidemic cerebrospinal meningitis;
Neisseria meningitidis;
group B;
drug sensitivity test;
multilocus sequence analysis;
ST-7962
- From:
Chinese Journal of Zoonoses
2025;41(1):47-52
- CountryChina
- Language:Chinese
-
Abstract:
Blood from a case of group B epidemic cerebrospinal meningitis identified in February 2024 in Ganzhou City,Jiangxi Province,and throat swabs from close contacts were collected for isolation and culture.The isolates were subjected to serogrouping,drug sensitivity testing,and whole genome sequencing and analysis,to provide a basis for epidemiological inves-tigation and clinical drug use.One strain of Neisseria meningitidis was isolated from the blood of the case and denoted group B.The MLST type was ST-7962,with no clonal group attribution.The phylogenetic tree showed that it was genetically close to the 1977 Shanghai carrier isolate(id-52231).Drug sensitivity results indicated that the strain was sensitive to 8 drugs:azithro-mycin,cefotaxime,minocycline,ceftriaxone,chloramphenicol,meropenem,rifampicin,and benzylpenicillin;resistant to cot-rimoxazole,levofloxacin,and ciprofloxacin;and showed an intermediate response to penicillin.This report describes the first case of ST-7962 group B meningoencephalitis found in Jiangxi Province.Monitoring of Neisseria meningitidis carriage,drug re-sistance,and molecular characteristics of strains in the healthy population in this region should be strengthened,to provide la-boratory support for the clinical use of medications,traceability,and control of the pathogen underlying meningoencephalitis infection.
