Drug resistance characteristics and whole genome polymorphisms of group A Streptococcus in Jiangsu Province during 2016 to 2023
10.3969/j.issn.1002-2694.2025.00.007
- VernacularTitle:江苏省2016-2023年A族链球菌耐药特征和全基因组多态性分析
- Author:
Jie HONG
1
;
Hao-di HUANG
1
;
Ke XU
1
;
Zhong-ming TAN
1
;
Hui-min QIAN
1
;
Jie-fu PENG
1
;
Xiao-xiao KONG
1
Author Information
1. 国家卫生健康委肠道病原微生物重点实验室,江苏省疾病预防控制中心,南京 210009
- Publication Type:Journal Article
- Keywords:
group A Streptococcus;
drug resistance;
emm type;
whole genome sequence
- From:
Chinese Journal of Zoonoses
2025;41(1):40-46
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed at understanding the relationships among the drug resistance and genome characteristics of group A Streptococcus in Jiangsu Province.A total of 149 group A Streptococcus strains were collected from hospitals between 2016 and 2023.Thirteen antimicrobial minimal inhibitory concentrations were detected with the micro-dilution broth method.The GAS strains were typed with emm genotyping analysis and whole genome sequencing,to determine the carriage rates of drug resistance genes and the evolutionary relationships among strains.The resistance rates of 149 GAS strains to erythromy-cin,tetracycline,and clindamycin exceeded 90％,whereas the strains showed sensitivity to 8 different antibiotics,including penicillin.Notably,the resistance rates to erythromycin,tetracycline,and clindamycin consistently increased over time.All strains were classified into 9 emm types,among which emm12 accounted for the highest proportion(77/149;51.68％).Signifi-cant statistical differences were observed among emm types,in terms of the drug resistance rate,number of resistant species,and prevalence of drug resistance genes.Furthermore,SNP evolutionary tree analysis revealed 3 distinct clusters within the GAS strains:emm12,emm1,and other emm types.emm 12 and emm1 were the dominant GAS strains in Jiangsu Province.Most isolates were resistant to erythromycin,tetracycline,and clindamycin.Differences in phenotypes and genomic characteris-tics were observed among emm types.
