Advances in the Research on Hypoxia in Biological Processes of Glioblastoma
10.3870/j.issn.1672-0741.24.08.015
- VernacularTitle:低氧在胶质母细胞瘤生物学过程中作用的研究进展
- Author:
Hui DENG
1
;
Mengxian ZHANG
1
Author Information
1. 华中科技大学同济医学院附属同济医院肿瘤科,武汉 430030
- Publication Type:Journal Article
- Keywords:
glioblastoma;
hypoxia;
hypoxia inducible factor;
microenvironment
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2025;54(4):587-592
- CountryChina
- Language:Chinese
-
Abstract:
The hypoxic microenvironment is one of the most distinctive features in solid tumors,shaping the microenviron-ment of cancer evolution and correlating with poor prognosis of patients.Transcriptional regulation mediated by hypoxia-induc-ible factors is an important modality in the mechanism of cellular sensing and adaptation to hypoxia.Recent studies have demon-strated that hypoxia plays a pivotal role in various biological processes,including tumor progression,autophagy,angiogenesis,the immune microenvironment,and metabolic reprogramming.This review comprehensively discusses the advances in under-standing hypoxia-driven biological processes within glioblastoma,laying a foundation for future targeted therapy aimed at tumor hypoxia.
