Progress on mechanism of IL-32 in transformation process of gastric"inflammation to cancer"
10.3969/j.issn.1000-484X.2025.09.035
- VernacularTitle:IL-32在胃"炎-癌"转化进程中的作用机制研究进展
- Author:
Weijian ZHANG
1
;
Yuqi WU
;
Dishu ZHOU
;
Shuya SONG
;
Xinxin HONG
;
Yifei XU
;
Tiantian CAI
;
Shaoju GUO
;
Huafeng PAN
;
Haiwen LI
Author Information
1. 广州中医药大学第四临床医学院,深圳 518033;广州中医药大学科技创新中心,广州 510006
- Publication Type:Journal Article
- Keywords:
IL-32;
Gastric"inflammation-cancer"transformation;
Gastric precancerous lesion;
Helicobacter pylori infection;
Immune microenvironment;
Macrophage polarization
- From:
Chinese Journal of Immunology
2025;41(9):2264-2271
- CountryChina
- Language:Chinese
-
Abstract:
IL-32 is a multifunctional cytokine with both pro-inflammatory and anti-inflammatory properties.It has been proved that expression of IL-32 increases with progression of gastric mucosal diseases and severity of gastric cancer(GC),thus participating in process of gastric"inflammation-cancer"transformation.However,how IL-32 affects malignant transformation of gastric"inflamma-tion-cancer"and finally leads to adverse outcome of GC invasion and migration is still controversial.In order to better clarify regulatory effect and possible mechanism of abnormal expression of IL-32 on different histopathological stages of gastric"inflammation-cancer"transformation,and to explore new directions and breakthroughs in molecular mechanism of early truncation and treatment of gastric precancerous lesion(GPL),we searched literatures related to IL-32 in six authoritative databases at home and abroad,such as Pubmed,Web of Science and CNKI,in past 30 years.It was found that pathogenicity or protective function of IL-32 in different histo-pathological stages of gastric"inflammation-cancer"transformation depended on its different subtypes,secretory forms,surrounding cytokine environment,disease status and genetic factors.IL-32 may regulate polarization of macrophages through NF-κB,MAPK,COX2,PR3,IDO,NOD,PKCδ,FAK and STAT3,amplify or inhibit chronic inflammatory stimulation of gastric mucosa,and thus participate in process of gastric"inflammation-cancer"transformation.Our new understanding of role of IL-32 in different stages of Cor-rea cascade may contribute to development of cytokine-directed therapy,and therapy aimed at regulating different alternative splicing subtypes of IL-32 and targeting IL-32 signals can be used as a new strategy for medical treatment of GPL and GC in future.
