Analysis of the effectiveness and acceptability of antidepressants in the treatment of postpartum depression
10.13699/j.cnki.1001-6821.2025.02.019
- VernacularTitle:抗抑郁药物治疗产后抑郁的有效性和可接受性分析
- Author:
Wen-feng LI
1
;
Ke XU
;
Xin WEN
;
Meng LI
;
Hai YUAN
;
De-rong KONG
;
Wei-feng MI
Author Information
1. 郑州市第八人民医院重症精神科,河南郑州 450015
- Publication Type:Journal Article
- Keywords:
antidepressants;
postpartum depression;
effectiveness;
acceptability;
network meta-analysis
- From:
The Chinese Journal of Clinical Pharmacology
2025;41(2):245-249
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically evaluate the effectiveness and acceptability of antidepressant drugs in the treatment of postpartum depression(PPD).Methods The PubMed,Cochrane Library,Embase,Web of Science,China National Knowledge Infrastructure(CNKI),Wanfang Database,VIP Journals of Chinese Scienc were searched,and Chinese Biomedical Literature Service System(SinoMed)database until November 2023.Screen randomized controlled trials(RCTs)of antidepressant drugs for the treatment of PPD.The treatment group was given antidepressant drugs,and the control group was given placebo or another antidepressant drug.Meta-analysis of effectiveness and acceptability is performed using Stata 17.0 software.Results A total of 27 RCTs with a total of 2 202 patients were included.The results of meta-analysis showed:The top three efficacy relative to placebo were mirtazapine[odds ratio(OR)=2.25,95％confidence interval(CI)=(1.20-3.30),P＜0.05],nortriptyline[OR=1.50,95％CI=(0.55-2.44),P＞0.05],venlafaxine[OR=1.35,95％CI=(0.13-2.56),P＞0.05].Acceptability is compared with placebo in the top three Chinese herbal medicine[OR=0.47,95％CI=(-0.72-1.66),P＞0.05],nortriptyline[OR=-0.08,95％CI=(-1.16-1.33),P＞0.05],venlafaxine[OR=-0.12,95％CI=(-1.47-1.24),P＞0.05].Conclusion Nortriptyline,venlafaxine,trazodone,and duloxetine are effective in treating PPD without obvious adverse drug reactions.
