Advances in the mechanism of left auricular thrombosis in patients with atrial fibrillation
- VernacularTitle:心房颤动患者左心耳血栓形成机制的研究进展
- Author:
Wenxiu LI
1
;
Zhenyu ZHU
;
Hui CHAI
;
Xiaoxuan ZHENG
;
Jing LU
;
Runqin LI
Author Information
- Publication Type:Journal Article
- Keywords: atrial fibrillation; atrial appendage; thrombosis
- From: Tianjin Medical Journal 2025;53(9):1005-1008
- CountryChina
- Language:Chinese
- Abstract: Atrial fibrillation(AF)is one of the most common clinical arrhythmias and a significant risk factor for thromboembolism.The left atrial appendage(LAA)is the primary site of thrombus formation in AF patients.Recent studies have explored the mechanisms of LAA thrombosis from multiple dimensions,including anatomical structure(LAA morphology and architecture),functional indicators(hemodynamic alterations),pathophysiological mechanisms(endothelial injury,inflammatory activation),systemic diseases(renal dysfunction)and genetic factors(gene polymorphisms),providing critical evidence for precise clinical anticoagulation.This article systematically reviews the latest research advances in the mechanisms of LAA thrombosis in AF patients,aiming to offer theoretical support for the accurate assessment of thromboembolic risk and the formulation of individualized anticoagulation strategies.Additionally,it lays the foundation for exploring the intrinsic relationship and mechanisms between LAA hemodynamics and heart failure as well as thromboembolic events.
