Mechanism of A20 in rheumatoid arthritis and progress of Chinese medicine intervention

VernacularTitle:A20在类风湿关节炎中的作用机制研究及中医药干预进展
Author: Yiying WU ¹ ; Yujia LIU ; Lei ZHENG ; Li LIU ; Xinyi CHEN ; Zhihua GUO
Author Information

1. 湖南中医药大学第一附属医院,长沙 410007;湖南中医药大学,长沙 410000
Publication Type:Journal Article
Keywords: Zinc finger protein A20; Rheumatoid arthritis; Traditional Chinese medicine; NF-κB
From: Chinese Journal of Immunology 2025;41(9):2123-2130
CountryChina
Language:Chinese
Abstract: Rheumatoid arthritis(RA)is an autoimmune disease characterized by chronic,aggressive joint inflammation,which seriously harms mental and physical health of patients.Efficacy of clinical drugs for RA is limited,so it is a hot issue to seek new therapeutic targets and drugs.Zinc finger protein A20,a cytoplasmic ubiquitin modifier,is closely related to negative regulation of nuclear factor-kappaB(NF-κB),an inflammatory signaling pathway,and has anti-inflammatory and anti-apoptotic effects.A20 is involved in pathogenesis of RA and can improve inflammatory response and bone destruction of RA.Treatment of RA by traditional Chinese medicine has unique advantages of multi-target and multi-pathway,and studies have found that traditional Chinese medicine has a regulatory effect on A20.This paper expounds mechanism of A20 in RA and research progress of traditional Chinese medicine intervention in A20,in order to provide references for treatment and drug development of RA.