Comparative study of single-criteria and multi-criteria optimization modes for cervical cancer VMAT radiotherapy plans by Raystation planning system
10.19745/j.1003-8868.2025160
- VernacularTitle:宫颈癌VMAT计划单目标优化方式与多目标优化方式在Raystation计划系统上的比较研究
- Author:
Gang LI
1
;
Yu-song LONG
1
;
Jun-wen TAN
1
;
Xian-tao HE
1
;
Yong-fu FENG
1
;
Zhan-yu WANG
1
Author Information
1. 柳州市工人医院肿瘤放射治疗室,广西 柳州 545005
- Publication Type:Journal Article
- Keywords:
multi-criteria optimization;
single-criteria optimization;
volumetric modulated arc therapy;
cervical cancer;
Raystation planning system;
dosimetric parameter
- From:
Chinese Medical Equipment Journal
2025;46(9):39-44
- CountryChina
- Language:Chinese
-
Abstract:
Objective To carry out cervical cancer VMAT radiotherapy planning respectively with the single-criteria optimization(SCO)and multi-criteria optimization(MCO)modes of Raystation 4.7 planning system,and to provide references for selecting optimization mode clinically by comparing and analyzing the dosimetric parameters such as target dose distribution,exposure dose to organ at risk(OAR),monitor unit and beam-on time.Methods Ten cervical cancer patients who attended some hospital from February to December 2022 were retrospectively selected,and some VMAT plans were designed for them with the SCO mode of Raystation 4.7 planning system and then enrolled into a SCO group;other VMAT plans were redesigned with the MCO mode under the premise the setup conditions such as machine model and shot field angle were unchanged,and divided into a MCO group.The two groups were compared in terms of maximum dose(D2%),minimum dose(D98%),homogeneity index(HI)and conformity index(CI)of the planning target volume(PTV),beam-on time,monitor unit and exposure doses to OARs including bladder V50 Gy,V40 Gy and V30 Gy,rectum V50 Gy,V40 Gy and V30 Gy,small intestine V50 Gy,V40 Gy and V30 Gy and left and right femur V50 Gy,V40 Gy and V30 Gy.SPSS 22.0 software was used for statistical analysis.Results Both the two groups met clinical requirements.There were no significant differences between the two groups in D98%,CI,small intestine V50 Gy and left and right femur V40 Gy(P>0.05).The MCO group had the values of HI,D2%,V50 Gy,V40 Gy and V30 Gy,rectum V50 Gy,V40 Gy and V30 Gy,small intestine V40 Gy and V30 Gy and left and right femur V30 Gy lower than those of the SCO group,with the differences being statistically significant(P<0.05).The SCO group had less monitor units and shorter beam-on time when compared with the MCO group,with the differences being statistically siginificant(P<0.05).Conclusion When compared with the SCO mode-based VMAT plans,the MCO mode-based VMAT plans significantly decrease the exposure doses and volume to rectum,bladder and small intestine and raise the PTV homogeneity,while lower the treatment efficiency to some extent by increased monitor units and prolonged beam-on time.[Chinese Medical Equipment Journal,2025,46(9):39-44]
