Effect of liraglutide on myocardial injury in diabetic rats through activation of Nrf2/HO-1 signaling pathway
- VernacularTitle:利拉鲁肽通过激活Nrf2/HO-1信号通路对糖尿病大鼠心肌损伤的影响
- Author:
Yuan GAO
1
;
Yu-liang WANG
1
;
Shao-lan WANG
1
Author Information
- Publication Type:Journal Article
- Keywords: diabetes mellitus; liraglutide; Nrf2; HO-1; pyroptosis; myocardial injury
- From: Chinese Pharmacological Bulletin 2025;41(3):538-543
- CountryChina
- Language:Chinese
- Abstract: Aim To explore the effect of liraglutide on myocardial injury in diabetic rats by activating Nrf2/HO-1 signaling pathway.Methods Forty rats were divided into thenormal group,model group,metformin group and liraglutide group.After modeling,the nor-mal group and model group did not intervene,the met-formin group was administrated with 250 g·kg-1 met-formin,and the liraglutide group was injected with 0.324 g·kg-1 liraglutide,once a day for a total of one month.Blood sugar and insulin levels were detec-ted by ELISA,and the pathological changes were ob-served by HE staining.The expression of Nrf2,HO-1,NLRP3,IL-1 β and caspase-1 were detected by West-ern blot and fluorescent quantitative PCR,respective-ly.Results Compared with the model group,the fasting glucose,NLRP3,caspase-1,IL-1β of the treatment group were reduced,while insulin,Nrf2,HO-1 levels increased(P＜0.05),of which the effects of liraglutide group was more obvious.Conclu-sions Liraglutide has a protective effect on diabetic myocardium,and its mechanism may be related to the regulation of Nrf2/HO-1 signaling pathway and the im-provement of pyroptosis.
