Changes of FAR and UHR in Elderly Patients with Type 2 Diabetic Kidney Disease and the Value of Early Diagnosis
10.11969/j.issn.1673-548X.2025.07.014
- VernacularTitle:FAR、UHR在老年2型糖尿病肾病患者中的变化及早期诊断价值
- Author:
Chenxi ZHU
1
;
Yingfei JIANG
;
Weiyi ZHOU
Author Information
1. 221002 徐州医科大学附属医院全科医学科
- Publication Type:Journal Article
- Keywords:
Type 2diabetes mellitus;
Elderly;
Diabetic kidney disease;
Fibrinogen to albumin ratio;
Uric acid/high-density lipo-protein cholesterol ratio
- From:
Journal of Medical Research
2025;54(7):72-76
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of fibrinogen/albumin ratio(FAR)and uric acid/high-density cholesterol ratio(UHR)in elderly patients with type 2diabetic kidney disease(DKD),as well as the value of the above indexes for early diagnosis of DKD.Methods 310 elderly type 2diabetes mellitus(T2DM)patients were selected and divided into 106 cases in the simple T2DM group,121 cases in the early DKD group and 83 cases in the clinical DKD group according to the urinary microalbumin/urine creatinine ratio(UACR),and the general data and laboratory data of the three groups were compared.Results With the increase of proteinuria,FAR and UHR were significantly elevated,and FAR and UHR were higher in the early DKD group and clinical DKD group than in the sim-ple T2DM group,and FAR was higher in the clinical DKD group than in the early DKD group,and the differences were statistically signif-icant(P＜0.05).Spearman's correlation analysis showed that both UHR and FAR were positively correlated with UACR(r=0.174,P=0.002;r=0.445,P＜0.001),UA(r=0.783,P＜0.001;r=0.147,P=0.010),Cr(r=0.392,P＜0.001;r=0.332,P＜0.001),and negatively correlated with eGFR(r=-0.114,P=0.045;r=-0.374,P＜0.001).In addition,UHR was positively correlated with FAR(r=0.147,P=0.010).The results of multiple Logistic regression analysis showed that long disease course,high glycated hemoglo-bin level,high systolic blood pressure,high FAR,and high UHR were risk factors for the occurrence of DKD(P＜0.05);among which long disease course,high FAR,and high UHR were risk factors for the occurrence of early DKD(P＜0.05).ROC curve analysis sugges-ted that FAR and UHR combined with disease duration had an important diagnostic value for the occurrence of early DKD(AUC=0.803,95％CI:0.752-0.853).Conclusion Elevated FAR and UHR are closely related to the development of DKD and may be independent risk factors for the occurrence of early DKD.Monitoring FAR and UHR in combination with urine microalbumin testing is benefical for the early diagnosis of DKD.
