Abnormal striatum functional connectivity in major depressive disorder: a resting state functional magnetic resonance imaging study
10.3760/cma.j.issn.1006-7884.2019.03.005
- VernacularTitle:抑郁症患者纹状体功能连接异常的静息态fMRI研究
- Author:
Feng CHEN
1
;
Guanmao CHEN
;
Jiaying GONG
;
Yanbin JIA
;
Shuming ZHONG
;
Zhangzhang QI
;
Shunkai LAI
;
Li HUANG
;
Ying WANG
Author Information
1. 暨南大学附属第一医院医学影像中心,广州,510630
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Magnetic resonance imaging;
Corpus striatum;
Functional connectivity
- From:
Chinese Journal of Psychiatry
2019;52(3):193-199
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristics of striatum functional connectivity (FC) in patients with major depressive disorder (MDD).Methods Fifty unmedicated patients with MDD and 48 healthy controls underwent resting-state functional magnetic resonance imaging (rs-fMRI) scan.Routine preprocessing of rs-fMRI data was performed.The striatum was divided into bilateral inferior ventral striatum,bilateral superior ventral striatum,bilateral dorsal caudate,bilateral dorsal caudal putamen,bilateral dorsal rostral putamen,and bilateral ventral rostral putamen.Whole brain functional connectivity analysis was performed with the above 12 seed points.And significant differences of each seed FC among two groups were calculated with Two-sample t-test and multiple comparison correction of threshold-free cluster enhancement (TFCE).Finally,correlation analysis was performed between the FC of the brain regions and clinical features (i.e.Hamilton Depression Scale of 24 items (HAMD24) scores).Results In comparison to the control group,the MDD patients showed significantly decreased FC in the left dorsal caudal putamen and the right superior temporal gyrus (t=-5.46,P＜0.008,TFCE correction),the right dorsal rostral putamen and bilateral postcentral gyrus (right t=-4.85,left t=-4.81,P＜0.008,TFCE correction) and left precuneus (t=-4.58,P＜0.008,TFCE correction).There were no significant correlations between the FC values in these regions and HAMD24 scores (r=0.171,0.002,0.005,0.098;all P＜0.05).Conclusion The MDD patients possibly have abnormal FC in the striatum and the superior temporal gyrus,the postcentral gyrus and the precuneus,and it suggests these sensorimoter areas may play an important role in the pathological mechanisms of MDD.
