Mechanism by which diabetes exacerbates intervertebral disc degeneration
- VernacularTitle:糖尿病加剧椎间盘退变的作用途径
- Author:
Jikun MA
1
;
Jianru WANG
;
Junjie QI
;
Haifei LIU
Author Information
- Publication Type:Journal Article
- Keywords: diabetes; intervertebral disc degeneration; cartilage endplate degeneration; apoptosis; advanced glycation end products; osmotic stress
- From: Chinese Journal of Tissue Engineering Research 2025;29(27):5907-5913
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:Diabetes exacerbates intervertebral disc degeneration in a number of ways,and good glycemic control is beneficial in preventing intervertebral disc degeneration.OBJECTIVE:To review the relationship between diabetes and intervertebral disc degeneration to provide a reference for the clinical treatment of disc degeneration in patients with diabetes.METHODS:Literature searches were performed in CNKI and PubMed databases for articles published from 1980 to 2023.The Chinese and English search terms were"diabetes,intervertebral disc degeneration,cartilage endplate degeneration,apoptosis,advanced glycation end products,osmotic stress."Finally,73 articles were included for summary and analysis.RESULTS AND CONCLUSION:(1)The pathophysiological process of diabetes-induced intervertebral disc degeneration is different from that of physiological degeneration.The main mechanisms of diabetes-induced intervertebral disc degeneration include:intracellular hyperglycemia,impaired blood supply to the intervertebral discs due to microvascular pathology,cellular senescence,apoptosis,and autophagy,accumulation of advanced glycation end products,osmotic stress,and destruction of the extracellular matrix components due to other pathways.(2)Drugs such as curcumin,resveratrol,and lupeol have therapeutic effects on intervertebral disc degeneration,but their safety and effectiveness need to be further demonstrated in clinical treatment.
