The effects of intermittent theta burst stimulation on the language function, communication ability and serum BDNF of stroke patients with motor aphasia
10.3760/cma.j.cn421666-20230913-00727
- VernacularTitle:间歇性θ节律经颅磁刺激左背外侧前额叶对脑卒中后运动性失语患者的影响
- Author:
Ri XU
1
;
Kunqiang YU
1
;
Kaimin MA
1
;
Lixiu WU
1
;
Minya ZHOU
1
Author Information
1. 丽水市第二人民医院康复医学科，丽水 323000
- Publication Type:Journal Article
- Keywords:
Stroke;
Aphasia;
Theta burst stimulation;
Neurotrophic factors
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2025;47(3):216-220
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of intermittent theta burst transcranial magnetic stimulation (iTBS) on the language use, daily communication, and serum brain-derived neurotrophic factor (BDNF) levels of stroke survivors with motor aphasia (PSMA).Methods:A total of 60 PSMA patients were recruited and randomly divided into a control group and a treatment group, each of 30. Both groups received conventional speech training, while the treatment group additionally received daily 10-minute iTBS stimulation over the left dorsolateral prefrontal cortex, five days per week, for two weeks. Before and after the treatment, language function and daily communication were assessed using the Chinese Rehabilitation Research Center Standard Aphasia Examination (CRRCAE) and the Communication Activities of Daily Living (CADL) scale. Serum BDNF levels were measured using enzyme-linked immunosorbent assay.Results:After treatment, the CRRCAE and CADL scores in the treatment group were significantly higher than among the control group. The post-treatment serum BDNF levels in the treatment and control groups were (27.03±6.91)ng/ml and (22.20±5.89)ng/ml, respectively, both significantly higher than their pre-treatment levels. The average post-treatment serum BDNF level in the treatment group was significantly higher than the control group′s average.Conclusions:iTBS stimulation with speech training can better improve the language function and daily communication ability of stroke survivors with motor aphasia. The mechanism may be related to increased serum BDNF level.
