Research Advances in Microscale-Engineered Tension Tissues Based on Flexible Microstructures
10.16156/j.1004-7220.2025.04.034
- VernacularTitle:基于柔性微结构的微尺度工程化牵张组织研究进展
- Author:
Zixing ZHOU
1
;
Wei CAI
1
;
Tingting LI
1
;
Zhun LIAO
1
;
Zuoqi ZHANG
1
;
Guoyou HUANG
1
Author Information
1. 武汉大学土木建筑工程学院,工程力学系,武汉 430072
- Publication Type:Journal Article
- Keywords:
engineered tension tissues;
tensile stimulation;
flexible microstructures;
biomechanics;
mechanical modeling
- From:
Journal of Medical Biomechanics
2025;40(4):1050-1060
- CountryChina
- Language:Chinese
-
Abstract:
Tensile stimulation plays a crucial role in regulating tissue structure and function.Due to the limitations of in vivo studies,engineered tension tissues(ETTs)based on biomaterials and tissue engineering technologies have gradually become a research hotspot.Specifically,microscale-engineered tension tissues(μETTs)based on flexible microstructures overcome many limitations of traditional ETTs,due to their controllable mechanical constraints and precise mechanical characterization and stimulation capabilities.This has led to their widespread applications in disease research,drug screening,and toxicologic studies.This review summarizes the materials and fabrication method of flexible microstructures,analyzes their biomechanical roles in μETTs,provides an overview of research progress in myocardial,lung,and skeletal muscle μETTs,discusses mechanical modeling and analysis methods during the remodeling of μETTs,and looks ahead to the future development of this field.
