Establishment and Evaluation of Psoriasis Rat Model with Blood-Heat Syndrome and Blood-Stasis Syndrome
- VernacularTitle:血热证与血瘀证银屑病大鼠模型的建立及证候差异评价
- Author:
Yibing YANG
1
;
Yuanyuan QIAO
;
Canzhe LI
;
Dongmei WANG
;
Jiangyong GU
Author Information
- Publication Type:Journal Article
- Keywords: Psoriasis; Traditional Chinese medicine syndrome type; Modeling method; Animal model; Model evaluation
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2025;27(8):2360-2372
- CountryChina
- Language:Chinese
- Abstract: Objective To establish and compare rat models of psoriasis with blood-heat syndrome and blood-stasis syndrome.Methods The blood-heat syndrome model was induced by compound heat potion decoction and imiquimod.The blood-stasis syndrome model was induced by fatigue,hunger,cold dampness,panic and imiquimod.The groups were evaluated for TCM syndromes,psoriasis lesions,pathological tissue,spleen index,hemorheology and key gene expression levels.Results The blood-heat syndrome model group showed significant differences from the control group in syndrome manifestations,PASI score,Baker score,spleen index and plasma viscosity(P<0.05).The blood-stasis model group showed significant differences from the control group in syndrome manifestations,body weight,PASI score,Baker score,spleen index,whole blood viscosity(60s-1),whole blood viscosity(10s-1)and plasma viscosity(P<0.05).The key gene expression levels were different among all syndrome groups.Conclusion The animal models had the typical features of psoriasis and matched the signs of blood-heat syndrome and blood-stasis syndrome of TCM.The models can provide a basis for explaining the scientific meaning of TCM syndrome differentiation in treating psoriasis.
