Research Progress of Animal Model of Spleen and Stomach Damp-Heat Syndrome under the Combination of Disease and Syndrome
- VernacularTitle:病证结合模式下脾胃湿热证动物模型研究进展
- Author:
Lin YU
1
;
Qinghua GAO
;
Yanping ZHOU
;
Shuhan ZHOU
;
Siyi ZHANG
;
Hailin YAN
;
Wenliang LYU
Author Information
- Publication Type:Journal Article
- Keywords: Combined model of disease and evidence; Spleen and stomach damp-heat syndrome; Animal model; Research progress
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2025;27(8):2323-2330
- CountryChina
- Language:Chinese
- Abstract: Objective To systematically sort out the current situation of animal model construction and evaluation of damp-heat syndrome of spleen and stomach under the pattern of combining disease and evidence,references for optimizing the standardized research of this syndrome were provided.Methods The references in the past 20 years from CNKI,Wanfang,VIP,PubMed and other databases were searched to summarize and analyze the modeling ideas,evaluation systems and problems of the animal models of spleen-stomach damp-heat syndrome.Results Most of the existing models used high-fat and high-sugar feeds combined with hot and humid environment exposure,compound pathogenic microbial infection or chemical stimulation to construct the combined disease and evidence model.The model validity was evaluated by macroscopic signs,gastrointestinal function indexes,inflammatory factors,and intestinal bacterial flora,etc.However,there were still problems of insufficient stability of the model,and inconsistencies in the criteria for evaluation of the evidence.Conclusion The combination of disease and evidence model can better simulate the clinical characteristics of spleen and stomach damp-heat syndrome,but it is necessary to strengthen the construction of multimodal evaluation system and molecular mechanism research.The standardization of animal models can be promoted through the integration of multidisciplinary technology,which can provide a more accurate method for the modernization of traditional Chinese medicine research.
