Research on the Factors Influencing the Evolution of COPD Qi Deficiency Syndrome Based on Nonlinear Mixed Effects Model
- VernacularTitle:基于非线性混合效应模型的慢性阻塞性肺疾病气虚证演变影响因素研究
- Author:
Weike LI
1
;
Mingyang YI
;
Yuanyuan NI
;
Lizhen YAN
;
Jianxin GUAN
;
Shihao WANG
;
Huijie WANG
;
Jiansheng LI
;
Zhiwan WANG
Author Information
- Publication Type:Journal Article
- Keywords: Nonlinear mixed effects model; Methodology; Syndrome evolution; Influencing factors; COPD; Qi deficiency syndrome
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2025;27(8):2205-2214
- CountryChina
- Language:Chinese
- Abstract: Objective To provide methodological examples for related research,the influencing factors of the evolution of Qi deficiency syndrome in chronic obstructive pulmonary disease(COPD)based on a nonlinear mixed effects model was explored.Methods A research questionnaire on the influencing factors of the evolution of Qi deficiency syndrome in chronic obstructive pulmonary disease was developed,and clinical data of 650 COPD patients on the 1st and 14th day of acute exacerbation,the 1st and 28th day of risk window,the first day of stable period,and the 90th day were dynamically collected from 10 tertiary hospitals across the country.8 baseline data including gender and age were collected through the PROC NLMIXED process by SAS 9.4 software.Coronary heart disease,diabetes and hypertension accounted for the highest proportion.Nine concurrent syndromes including wind cold syndrome and phlegm heat syndrome were used as fixed effects,and individual level was used as random effects to gradually fit the model and screen the influencing factors of Qi deficiency syndrome in the entire process of disease occurrence and development.Results A total of 637 eligible cases were included,and clinical datas were dynamically collected on the 1st and 14th day of acute exacerbation,the 1st and 28th day of the risk window,the 1st and 90th day of the stable period.It was found that the number of acute exacerbations,alcohol consumption,concomitant hypertension,coronary heart disease,blood stasis syndrome,yin deficiency syndrome,yang deficiency syndrome,6-minute walking distance,and the modified Medical Research Council Dyspnea Questionnaire(mMRC)had an impact on the evolution of Qi deficiency syndrome in the previous year(P<0.05).Conclusion The use of a nonlinear mixed effects model revealed the relevant factors affecting the evolution of Qi deficiency syndrome from complex multi temporal dynamic data,providing methodological references for other related studies.
