Study on the Effect of Cuproptosis on Diabetic Cardiomyopathy Based on"Qi Collateral Theory"
- VernacularTitle:基于"气络学说"探讨铜死亡对糖尿病心肌病的影响
- Author:
Yuting LIN
1
;
Kun YU
;
Fei CHEN
;
Bin LI
;
Qiufang OUYANG
;
Jinjian GUO
Author Information
- Publication Type:Journal Article
- Keywords: Diabetic cardiomyopathy(DCM); Qi Luo Theory; Cuproptosis; Traditional Chinese medicine; Integrated traditional Chinese and Western medicine
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2025;27(8):2176-2182
- CountryChina
- Language:Chinese
- Abstract: Diabetic cardiomyopathy(DCM)is one of the complications of diabetes.The onset of DCM is hidden and easy to be ignored.Myocardial injury is serious in the later stage and the prognosis is poor.At present,symptomatic treatment is the main clinical treatment.Cuproptosis is a novel cell death mode caused by imbalanced copper ion concentration in the body,leading to mitochondrial metabolic abnormalities,which is one of the important mechanisms of DCM.Targeted cuproptosis pathway therapy for DCM is currently a focus and hotspot of research.The"Qi Luo Theory"is one of the disciplinary branches of the theory of collateral diseases,which mainly operates the meridian Qi system.The syndrome and treatment system of collateral diseases cardiovascular diseases have important guiding significance for the treatment of DCM.Traditional Chinese medicine believes that deficiency and stagnation of Qi that in the collaterals are the root causes of DCM,with stasis and toxin obstructing collaterals and damage to the heart collaterals being the core of the disease.The ultimate outcome is the deficiency and decline of Qi,Blood,Yin,and Yang in the heart.The"Qi Luo Theory"and cuproptosis have similarities in physiological functions and pathological processes,and cuproptosis can be said to be one of the microscopic manifestations of the"Qi Luo theory".Based on this,the staged treatment principle of tonifying deficiency and promoting stagnation as the norm,attacking and supplementing simultaneously as the principle,and strengthening the body and consolidating the core has been proposed,in order to provide theoretical reference for the clinical treatment of DCM.
