Optimal parameters for physical interventions in bone marrow mesenchymal stem cell differentiation
10.12307/2025.622
- VernacularTitle:物理方法干预骨髓间充质干细胞分化最理想的参数
- Author:
Xun LIU
1
;
Hougan OUYANG
1
;
Rongbin PAN
1
;
Zi WANG
1
;
Fen YANG
1
;
Jiaxuan TIAN
1
Author Information
1. 江西中医药大学,江西省南昌市 330004
- Publication Type:Journal Article
- Keywords:
bone marrow mesenchymal stem cell;
osteogenic differentiation;
chondrogenic differentiation;
physical factor;
mechanical transduction;
stem cell;
tissue engineering
- From:
Chinese Journal of Tissue Engineering Research
2025;29(31):6727-6732
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:In recent years,it has been found that physical interventions play a significant role in influencing proliferation,differentiation,and migration of bone marrow mesenchymal stem cells.However,the current physical intervention still exists such as basic research data to be strengthened,unified parameter standards need to be further improved and other shortcomings.OBJECTIVE:To review the effects of physical interventions on the differentiation of bone marrow mesenchymal stem cells.METHODS:PubMed and CNKI databases were searched for relevant articles using"bone marrow mesenchymal stem cells(BMSC),bone marrow stromal cells,osteogenesis differentiation,chondrocytes differentiation,electrical stimulation,mechanical stimulation,hypoxia,electromagnetic fields,low intensity pulsed ultrasound"as English and Chinese search terms.A total of 58 articles were selected for review.RESULTS AND CONCLUSION:(1)Physical interventions have been applied to regulate the proliferation and differentiation of bone marrow mesenchymal stem cells by altering specific microenvironments,but the parameters have not yet been unified.The future investigation should further optimize and explore the best parameters and conditions of action of the relevant physical factors on the role of bone marrow mesenchymal stem cell proliferation and differentiation.(2)It is difficult to carry out the application of certain special physical environmental conditions through low-cost conventional means,pending subsequent research and development to further reduce the difficulty of constructing special physical conditions.(3)The use of physical factors to rationally intervene in differentiation and proliferation of bone marrow mesenchymal stem cells has not yet been widely applied in the clinic,and further research is needed to promote clinical translation in the future.
