Association between prognostic nutritional index and coronary heart disease in US adult population—A cross-sectional analysis based on NHANES data from 2017 to 2020
10.3969/j.issn.1008-0074.2025.04.12
- VernacularTitle:预后营养指数与成年人群冠心病的相关性
- Author:
Zhong-shuai ZHAO
1
;
Yu-feng XUE
;
Chuan-bin ZHAO
;
Meng-dong HUANG
;
Sheng-yun SHANG
Author Information
1. 山东大学齐鲁医院德州医院(德州市人民医院)康复医学中心,山东德州 253000
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Nutrition assessment;
Prognosis
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2025;34(4):497-503
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between the prognostic nutritional index(PNI)and the prevalence of coronary heart disease(CHD)in adults.Methods:A cross-sectional analysis was conducted based on the 2017-2020 National Health and Nutrition Examination Survey(NHANES)database.A total of 12,141 adult participants were initially included and divided into CHD group and control group according to the disease status questionnaire.PNI was calculated using serum albumin level and lymphocyte count.Multivariable logistic regression was applied to explore the association between PNI and the prevalence of CHD in adults.Subgroup analysis was conducted to assess whether this association remained consistent across different populations.A restricted cubic spline model was con-structed to clarify the dose-response relationship between PNI and CHD prevalence in adults.Results:Among the 3,894 adult participants,200(5.14％)had CHD.The PNI level in CHD patients was significantly lower than that of the control group[(49.20±8.59)vs.(51.57±4.80),P＜0.001].Multivariable logistic regression analysis showed that,after adjustment for sex,age,race,marital status,body mass index(BMI),hypertension,diabetes and family history of cardiovascular disease,an increase in PNI was still independently associated with a lower prev-alence of CHD(odds ratio[OR]=0.92,95％CI 0.89～0.94,P＜0.001).The dose-response relationship indica-ted a negative linear correlation between PNI and CHD prevalence(P＜0.001).Subgroup analysis showed that the association between PNI and CHD differed significantly across BMI,hypertension and diabetes subgroups(P for in-teraction＜0.05 or＜0.01).Conclusion:Increasing PNI was significantly associated with a lower prevalence of CHD in adults,and this association was more pronounced in specific high-risk populations,such as those with obe-sity,hypertension,and diabetes.Our findings suggest that maintaining good nutritional status is of great significance in reducing the risk of CHD.
