Advances in mechanism of mitochondrial quality control system in endometriosis
- VernacularTitle:线粒体质量控制系统在子宫内膜异位症中作用机制的研究进展
- Author:
Yuan-huan CHEN
1
;
Bin YUE
;
Hai-yan MAO
;
Can-can HUANG
;
Xiao-hua ZHANG
;
Peng FENG
;
Quan-sheng WU
Author Information
- Publication Type:Journal Article
- Keywords: endometriosis; mitochondrial quality control sys-tem; oxidative stress; autophagy; kinetics; biogenesis; calcium homeostasis
- From: Chinese Pharmacological Bulletin 2025;41(3):406-410
- CountryChina
- Language:Chinese
- Abstract: Endometriosis(EMs)is a common estrogen-depend-ent clinical disease with the pathological characteristics of malig-nant tumors,which has great impact on women's physical and mental health.In recent years,experimental exploration has re-vealed that ectopic foci are in a hypoxic environment outside the uterine cavity,and mitochondria,as the"functional factories"of the cells,play an important role in the process of planting and in-vasion,and the mitochondrial quality control system,which in-cludes mitochondrial oxidative stress,kinetics,autophagy,bio-genesis and calcium homeostasis,is a key mechanism for the e-quilibrium of the mitochondrial function.The mitochondrial quality control system,including mitochondrial oxidative stress kinetics,autophagy,biogenesis and calcium homeostasis,is a key mechanism for mitochondrial functional balance.Therefore,to clarify the role of the mitochondrial quality control system in the development of EMs with the help of rational and rigorous experi-mental and clinical studies can not only help to clarify the patho-genesis of the disease,but also explore the key targets in the prevention and treatment of the disease.Therefore,this article summarizes the research progress of mitochondrial quality control system in endometriosis,with a view to providing reference and theoretical basis for the etiology,pathogenesis and prevention strategies of EMs.
