Research progress on mechanism of cGAS-STING pathway mediated cerebral ischemia/reperfusion injury
- VernacularTitle:cGAS-STING通路介导脑缺血/再灌注损伤的机制研究进展
- Author:
Meng-ya LI
1
;
Rui LAN
;
Xiao-ming SHEN
;
Shui-zhi JIAO
;
Ya-han LIU
;
Bao-qi WANG
Author Information
- Publication Type:Journal Article
- Keywords: cerebral ischemia/reperfusion; cGAS-STING path-way; cell apoptosis; neuroinflammation; iron autophagy; calci-um overload
- From: Chinese Pharmacological Bulletin 2025;41(3):417-420
- CountryChina
- Language:Chinese
- Abstract: Cyclic GMP-AMP synthase(cGAS)is a congenital immune sensor that can recognize cytoplasm abnormal dsDNA.By catalyzing the second messenger cyclic GMP-AMP(cGAMP)formation,it activates stimulator of interferon genes(STING),releases type Ⅰ interferon and inflammatory cytokines,activates the host immune response,and participates in cerebral ischemia reperfusion injury(CIRI)cascade reaction.This article reviews the research progress of the mechanism of cGAS-STING signaling pathway participation in CIRI,hoping to provide ideas for its treatment.
