Relationship between MTHFR polymorphism and the effect of hyperbaric oxygenation combined with drug therapy in the patients with profound sudden deafness
10.3760/cma.j.issn.1009-6906.2019.05.008
- VernacularTitle:亚甲基氢叶酸还原酶多态性与全聋型突发性聋患者高压氧和药物治疗效果的关系
- Author:
Jian GU
1
;
Jing XU
1
;
Bei ZHONG
1
;
Shaomei LIN
1
;
Jine WAN
1
Author Information
1. 青岛大学附属医院, 山东省青岛,266003
- Publication Type:Journal Article
- Keywords:
MTHFR;
Polymorphism;
Hyperbaric oxygenation;
Sudden deafness
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2019;26(5):416-418
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of gene mutation on sudden deafness through investigation on the relationship between MTHFR C677T polymorphism and the effect on such patients, so as to provide solid evidence for the treatment of sudden deafness. Methods Samples of venous blood in 99 patients with profound sudden deafness were collected and DNA was extracted from them. Real-time PCR was used for SNP genotyping of MTHFR gene. The patients underwent HBO and drug therapy and therapeutic effects were observed, then, the relationship between different genotypes and therapeutic effects were compared. Results The mutation types and frequencies of MTHFR genotype in the study population were: C/C 17. 17％, C/T 51. 51％ and T/T 31. 32％. The effective rate in the patients with profound sudden deafness treated with HBO and drug therapy was 75. 76％, and there was no statistical significance in the distribution of C/C and C/T+T/T genotypes, when comparisons were made between the effective and non-effective groups(P>0. 05). Conclusion Study results revealed that MTHFR gene polymorphism was not associated with the efficacy of HBO combined with drug therapy in the patients with profound sudden deafness.
