Observation on the resting?state fMRI functional connectivity of the anterior cingulate cortex in unipolar and bipolar depression
10.3760/cma.j.issn.1006-7884.2019.05.008
- VernacularTitle:单相和双相抑郁障碍患者前扣带回功能连接特征差异观察
- Author:
Sijia LIU
1
;
Hua GUO
;
Ruihua MA
;
Panqi LIU
;
Jing SHI
;
Jing AN
;
Yunlong TAN
;
Shuping TAN
;
Fude YANG
;
Zhiren WANG
Author Information
1. 北京大学回龙观临床医学院科技处北京回龙观医院 100096
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Bipolar disorder;
Magnetic resonance imaging;
Gyrus cinguli
- From:
Chinese Journal of Psychiatry
2019;52(5):339-346
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the functional connection(FC) between the anterior cingulate cortex (ACC) and other brain regions in unipolar depression(UD) and bipolar depression(BD), and the correlation to the severity of depressive symptoms. Methods 30 patients who met the diagnosis criteria of unipolar depression in DSM?Ⅳ and another 30 patients who met the diagnosis criteria of bipolar depression in DSM?Ⅳ were matched with 32 healthy controls(HC) by gender?, age?, and education. All subjects completed the resting?state functional magnetic resonance scans. After the imaging preprocessing, seed?based functional connectivity analysis was performed on the bilateral ACC. Pearson correlation analysis was performed between the FC values and the severity of depressive symptoms (measured by HAMD17 scores). Results (1) Compared to the health controls, the connectivity between the left ACC (LACC) and the left triangular part of the inferior frontal gyrus(t=3.48) and the connectivity from the LACC to the left inferior parietal gyrus(t=3.15) in patients with unipolar depression significantly increased, so did the connectivity between the right ACC(RACC) and the left triangular part of the inferior frontal gyrus(t=3.52); (2) Compared to the healthy controls, the connectivity from LACC to the right middle temporal gyrus (t=-4.00) in patients with bipolar depression significantly decreased, so did the connectivity between RACC and the other regions induding the left postcentral(t=-3.46), the right superior temporal gyrus(t=-2.86) and the right middle temporal gyrus(t=-3.40);(3)Compared to the patients with bipolar depression,patients with unipolar depression increased connectivity between the LACC and the other regions including the left triangular part of the inferior frontal gyrus(t=3.58), the right triangular part of the inferior frontal gyrus(t=4.06), the right middle temporal gyrus (t=3.25), the left inferior parietal gyrus(t=3.27), and the right inferior parietal gyrus(t=3.99). While the RACC increased its connectivity to the left triangular part of the inferior frontal gyrus(t=3.13), the left inferior parietal gyrus(t=3.42), and the right inferior parietal gyrus(t=3.78) (Alphasim?corr, P<0.001); (4) The severity of depressive symptoms were found uncorrelated to the FC value changes among the different regions(-0.20.05). Conclusion The results suggest that there are much difference in the brain function activity between UD and BD. The connectivity between ACC and other regions is stronger in UD patients, while weaker in BD patients, therefore the FC value could be possibly explored as an independent future biomarker to distinguish BD from UD regardless the symptoms severity.
