The role and research progress of m6A modification in sepsis and its induced multi-organ dysfunction disease
- VernacularTitle:m6A修饰在脓毒症及其诱发的多器官功能障碍疾病中的作用及研究进展
- Author:
Lu-lu ZHANG
1
;
Rui GONG
;
Jin-yi ZHAO
;
Fei MU
;
Yan-ping YIN
;
Wang-ting LI
;
Ling-ling ZHENG
;
Yu-ping TANG
;
Jing-wen WANG
Author Information
- Publication Type:Journal Article
- Keywords: m6A modification; sepsis; immunosuppression; hy-perinflammation; post-transcriptional regulation; multiple organ dysfunction
- From: Chinese Pharmacological Bulletin 2025;41(3):421-427
- CountryChina
- Language:Chinese
- Abstract: Sepsis is a life-threatening organ dysfunction disease caused by a dysregulated host response to infection.It has com-plex pathophysiological changes,and in severe cases,it can rap-idly develop into septic shock and multiple organ dysfunction or multiple organ failure.At present,the pathological mechanism of sepsis and its induced organ dysfunction is complex and the in-fluencing factors are numerous.So far,there is still a lack of specific and effective treatment strategies.RNA modify-N6-methyladenosine(m6 A)is one of the most common post-tran-scriptional modifications on eukaryotic RNAs.It is involved in the regulation of the occurrence and development of a variety of inflammatory diseases,including sepsis,and even multiple organ dysfunction induced by sepsis by affecting the metabolism of RNAs.It includes cardiac dysfunction,acute lung injury(ALI)and acute kidney injury(AKI).Therefore,this article will dis-cuss the effect of m6A modification on the function of immune cells,and its important role in sepsis and its induced multiple or-gan dysfunction diseases by regulating inflammatory signals,py-roptosis,mitochondrial damage and ferroptosis.This will provide new therapeutic targets and strategies for the clinical prevention and treatment of sepsis and its induced multiple organ dysfunc-tion diseases.
