Exosome in HIV infection：Mechanistic roles and translational potential
10.3760/cma.j.cn112866-20250728-00157
- VernacularTitle:外泌体在HIV感染中的作用及应用前景
- Author:
Ning DING
1
;
Jiajun LI
1
;
Aiwei ZHU
1
;
Bin SU
1
Author Information
1. 首都医科大学附属北京佑安医院 感染性疾病临床研究中心 中法艾滋病研究联合实验室，北京 100069
- Publication Type:Journal Article
- Keywords:
Exosome;
Human immunodeficiency virus（HIV）;
Infection
- From:
Chinese Journal of Experimental and Clinical Virology
2025;39(5):652-659
- CountryChina
- Language:Chinese
-
Abstract:
Exosome play a crucial role in human immunodeficiency virus（HIV）infection. They share high similarities with HIV virions in physicochemical properties and secretion mechanisms：both the formation and secretion of exosome and the budding of HIV depend on the endosomal sorting complex required for transport（ESCRT）complex and VPS4 protein，with their membrane structures being phospholipid bilayers and comparable ranges of diameter and density. These similarities pose challenges to related research. Exosome participate in HIV infection through multiple mechanisms，including promoting HIV entry，inhibiting HIV replication，activating HIV latent reservoirs，and engaging in host antiviral immune responses. In terms of clinical applications，the potential of exosome as biomarkers or vaccine carriers has attracted attention，showing translational prospects. In summary，exosome influence the progression of HIV infection through complex mechanisms，and their application prospects in diagnostic markers，vaccine development，and therapeutic targets merit in-depth exploration.
