Mechanism of action of cholangiocyte senescence in cholestatic liver disease and retated targeted therapies
- VernacularTitle:胆管细胞衰老在胆汁淤积性肝病中的作用机制及其靶向治疗进展
- Author:
Huaming XU
1
;
Liu YANG
;
Wuling YAN
;
Sijia ZHENG
;
Nian YANG
;
Yanxin LIU
Author Information
- Publication Type:Journal Article
- Keywords: Cholestasis; Cholangiocytes; Cellular Senescence
- From: Journal of Clinical Hepatology 2025;41(8):1708-1714
- CountryChina
- Language:Chinese
- Abstract: Cholestatic liver disease(CLD)is a liver condition caused by disorders in bile acid secretion and metabolism due to various reasons,and it has the common pathological features of various chronic liver diseases.In recent years,the role of cholangiocyte senescence(CS)in the pathogenesis of CLD has attracted more and more attention,and CS not only participates in the development and progression of CLD,but it is also significantly associated with the course and prognosis of the disease.Targeted clearance of senescent cholangiocytes or blocking senescence-related pathways can improve CLD.This article summarizes the role of CS in CLD,related influencing factors,and the research advances in CLD,in order to provide a theoretical reference for subsequent studies on CLD.
