Role of mitophagy induced by the PTEN-induced kinase 1/Parkin signaling pathway in metabolic associated fatty liver disease and related advances in targeted therapies
- VernacularTitle:PINK1/Parkin信号通路介导的线粒体自噬在代谢相关脂肪性肝病中的作用及靶向治疗研究进展
- Author:
Shengjin ZHU
1
;
Xiaodeng ZHU
;
Kaiyang LI
;
Mei YANG
;
Xian WU
Author Information
- Publication Type:Journal Article
- Keywords: Metabolism-Associated Fatty Liver Disease; Mitophagy; PINK1/Parkin Signaling Pathway
- From: Journal of Clinical Hepatology 2025;41(8):1655-1661
- CountryChina
- Language:Chinese
- Abstract: Metabolic associated fatty liver disease(MAFLD)has a complex pathogenesis,and mitophagy is involved in the development and progression of MAFLD and plays a key role in liver metabolic pathways and signaling networks.Mitophagy is regulated by a variety of pathways,and the PTEN-induced kinase 1(PINK1)/Parkin pathway is considered the main pathway for regulating mitophagy.Mitophagy mediated by the PINK1/Parkin pathway can regulate lipid metabolism,inflammation,and fibrosis and delay the progression of MAFLD.This article reviews the role of mitophagy mediated by the PINK1/Parkin pathway in MAFLD and the research advances in targeted therapy,in order to provide theoretical bases and ideas for the prevention and treatment of MAFLD.
