Research progress on physiological and pathological functions of salt-inducible kinase and its inhibitors
10.12092/j.issn.1009-2501.2024.11.014
- VernacularTitle:盐诱导激酶生理病理功能及其抑制剂的研究进展
- Author:
Xinyue LIN
1
;
Yanyan WANG
1
;
Hongsheng BIAN
1
;
Shuang YU
1
;
Lili HUANG
1
Author Information
1. 黑龙江中医药大学药学院,哈尔滨 150040,黑龙江
- Publication Type:Journal Article
- Keywords:
salt-inducible kinase;
central nervous system;
metabolism;
inflammation;
osteoarthritis;
cancer;
melanin
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(11):1306-1314
- CountryChina
- Language:Chinese
-
Abstract:
The salt-inducible kinase(SIK)family includes three isoforms,SIK1,SIK2 and SIK3,which are the main regulators of physiological and patho-logical processes and participate in the regulation of glucose and lipid metabolism,tumor,inflamma-tion,depression,sleep-wake and circadian rhythm.SIK inhibitor has become a candidate drug for the treatment of a variety of diseases,and is especially expected to become a potential new drug for the treatment of nervous system diseases,such as sleep disorders,circadian rhythm disorders,and de-pression.This review summarizes the regulation and mechanism of three isoforms of SIK and their upstream and downstream signaling pathways in the above physiological and pathological processes.It also reviews the recentstudies of SIK inhibitors.
