The crosstalk mechanism of intestinal barrier dysfunction in the pathogenesis of hepatorenal syndrome-acute kidney injury
- VernacularTitle:肠道屏障功能障碍在肝肾综合征-急性肾损伤发病中的串扰机制
- Author:
Wen SUN
1
;
Xiao CHEN
1
;
Xin ZHANG
1
;
Borui YU
1
;
Bo YANG
1
;
Haitao XING
1
Author Information
- Publication Type:Journal Article
- Keywords: Intestinal Barrier; Liver Cirrhosis; Hepatorenal Syndrome; Acute Kidney Injury; Bacterial Translocation
- From: Journal of Clinical Hepatology 2025;41(8):1685-1692
- CountryChina
- Language:Chinese
- Abstract: In 2015,the International Ascites Club proposed a new definition of hepatorenal syndrome-acute kidney injury based on the progression of hepatorenal syndrome,and studies are still being conducted to explore the exact pathogenesis of hepatorenal syndrome-acute kidney injury.Intestinal barrier plays an important bridging role in liver-kidney connection,and intestinal flora disturbance,bacterial translocation,and endotoxins entering the blood cause damage to the kidneys by releasing proinflammatory cytokines and activating immune-related cells.The entrance of bile acid into the circulation system also directly or indirectly lead to the development and progression of hepatorenal syndrome-acute kidney injury.This article reviews the crosstalk mechanism of hepatorenal syndrome-acute kidney injury from the perspective of the intestinal barrier and further clarifies the key role of the liver-gut-kidney axis in the pathogenesis of this disease,in order to provide new treatment ideas.
