Progress in the mechanisms of Toxoplasma gondii migration into the brain and intracranial anti-infection research
10.3969/j.issn.1002-2694.2025.00.092
- VernacularTitle:刚地弓形虫迁移入脑机制及脑内抗感染研究进展
- Author:
Jing LI
1
;
Shiyu LI
1
;
Yizhuo ZHANG
1
;
Bin ZHENG
1
Author Information
1. 杭州医学院基础医学与法医学院,杭州 310000
- Publication Type:Journal Article
- Keywords:
Toxoplasma gondii;
migration;
CNS;
restrictive cell barrier;
inflammation
- From:
Chinese Journal of Zoonoses
2025;41(7):762-766
- CountryChina
- Language:Chinese
-
Abstract:
Toxoplasma gondii is an obligate intracellular parasite that can invade the central nervous system(CNS)and cause complications such as encephalitis and schizophrenia.To migrate into the brain,T.gondii must cross restrictive cell barriers(blood-brain barrier,blood-cerebrospinal fluid barrier,and meninges).T.gondii migrates into the brain through transcellular or/and paracel-lular invasion and"Trojan horse"mechanisms,alone or in combination.The excessive inflammatory response after T.gondii infection destroys the blood-brain barrier and increases its permeability,thus further promoting the migration of T.gondii into the brain and causing persistent infection of the central nervous system.This review focuses on the mechanisms through which T.gondii migrates into the brain and the anti-T.gondii responses of brain parenchymal cells,to provide a deeper understanding of the pathogenic mecha-nisms of T.gondii and to offer insights for the development of novel therapeutic strategies.
