Analysis of the therapeutic efficacy of hyperbaric oxygen combined with Yangxueqingnao granules for the treatment of tinnitus and dizziness in patients with sudden deafness
10.3760/cma.j.issn.1009-6906.2018.03.004
- VernacularTitle:高压氧联合养血清脑颗粒治疗突发性聋患者耳鸣及头晕的疗效分析
- Author:
Xiaoling PENG
1
;
Xianrong ZENG
;
Fuqiong PAN
;
Qingming XIE
;
Huping CHEN
;
Mei PENG
Author Information
1. 四川省人民医院高压氧科,成都,610072
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Yangxueqingnao granule;
Sudden deafness;
Tinnitus;
Dizziness;
Randomized controlled trial
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2018;25(3):146-150
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effects of hyperbaric oxygen (HBO) combined with Yangxueqingnao granules on tinnitus and dizziness in patients with sudden deafness.Methods One hundred and twenty-four patients admitted into the Sichuan Provincial People's Hospital from March 2015 to June 2016 were randomly assigned to the observation group (n =61) and the control group (n =63) by using the random digital software to generate random number and opaque envelope hidden test scheme.The control group only received routine therapy,including improvement of circulation,nerve nutrition,hormone and symptomatic treatment,while the observation group was supplemented with HBO + Yangxueqingnao granules in addition to routine therapy.The observation group received HBO therapy one session a day,5 days a week and 10 days a treatment course.In addition,the patients in the observation group had Yangxueqingnao granules orally,one pack once and 3 times a day.After 2 weeks of treatment,therapeutic efficacy of the 2 groups was evaluated by the blinded method,and after 3 and 6 months of treatment,therapeutic effects on tinnitus and dizziness of the 2groups were evaluated through medical follow-ups by telephone.Results All the patients of the 2 groups had tinnitus,the observation group had 42 cases of dizziness,while the control group had 36 cases of dizziness.Following treatment for 2 weeks,3 and 6 months,total effective rates of tinnitus in the observation group were respectively 83.61％,75.41％ and 77.05％,which were all higher than those of the control group (65.08％,57.14％,58.73％),and statistical significance could be noted when comparisons were made between the 2 groups (P ＜ 0.05).Total effective rate of dizziness in the observation group after 2 weeks,3 and 6 months of treatment was 95.23％,which was obviously better than those of the control group (75.00％,80.56％,83.33％),and statistical significance could also be seen when comparisons were made between the 2 groups (P ＜ 0.05).Conclusions HBO combined with Yangxueqingnao granules in the treatment of patients with sudden deafness complicated with tinnitus and dizziness could produce good clinical effects.For this reason it was worth further clinical promotion.
