Advances in the role and mechanism of ISG15 in malignant tumours of the gastrointestinal tract
10.3969/j.issn.1006-5725.2024.23.019
- VernacularTitle:干扰素刺激基因15在消化道恶性肿瘤中的作用及机制研究进展
- Author:
Ping JIANG
1
;
Xiaoqin LUO
;
Shaoqian ZHAI
;
Chengzhu CAO
;
Zhanhai SU
Author Information
1. 青海大学医学院基础医学部(青海西宁 810001)
- Publication Type:Journal Article
- Keywords:
ISG15;
gastrointestinal malignant tumours;
new targets for the treatment
- From:
The Journal of Practical Medicine
2024;40(23):3394-3404
- CountryChina
- Language:Chinese
-
Abstract:
Interferon-stimulating gene 15(ISG15),an ubiquitin-like molecule belonging to the superfamily of ubiquitin-like proteins,is highly expressed in various malignant tumors and induced by type Ⅰ interferon.How-ever,its specific regulatory mechanism remains unclear.Numerous studies have demonstrated its close association with tumorigenesis and development.In this study,we provide a comprehensive review on the role of ISG15 protein in hepatocellular carcinoma,esophageal carcinoma,gastric carcinoma,colorectal carcinoma,and other cancers.Our aim is to identify new therapeutic targets for gastrointestinal malignancies and improve prognostic assessment.
