Effects of TREM2 on synaptic plasticity induced by cocaine addiction
- VernacularTitle:髓系细胞触发受体2对可卡因成瘾损伤神经突触可塑性的作用
- Author:
Rui-ke XU
1
;
Zhi-wen WANG
1
;
Jiao-jiao OUYANG
1
;
Qi DU
1
;
Li-hua LI
1
;
Shi-jun HONG
1
;
Yan-xia PENG
1
;
Gen-meng YANG
1
Author Information
- Publication Type:Journal Article
- Keywords: cocaine; drug addiction; TREM2; synap-tic plasticity; SYN1; PSD-95
- From: Chinese Pharmacological Bulletin 2025;41(12):2341-2347
- CountryChina
- Language:Chinese
- Abstract: Aim To investigate the role of triggering receptor expressed on myeloidcells 2(TREM2)in syn-aptic plasticity induced by cocaine addiction.Methods C57BL/6J mice and Trem2 knockout mice were uti-lized in this study to evaluate the alterations in postsyn-aptic density protein 95(PSD-95)and synapsin 1(SYN1)within the cortex and hippocampus of co-caine-addicted mice by using immunological tech-niques.Results HE staining and Nissl staining showed increased neuronal damage in the hippocampus and cortex of mice after cocaine addiction.The results of immunohistochemistry and fluorescence of PSD-95 and SYN1 were consistent with the expression trend of Western blot.In the wild type mouse model,the ex-pression level of PSD-95 in the hippocampus and cortex was lower than that in the saline group,and the ex-pression of SYN1 was higher than that in the saline group.In the knockout mouse model,the expression levels of PSD-95 and SYN1 in the hippocampus and cortex were significantly higher than those in the saline group after cocaine addiction.The expression levels of PSD-95 and SYN1 in the hippocampus and cortex of cocaine knockout mice were higher than those of co-caine wild type mice.Conclusion Cocaine addiction can change the synaptic plasticity,and TREM2 plays a regulatory role in the synaptic plasticity of hippocampus and cortex in mice with cocaine injury.TREM2 is ex-pected to be a new target for studying the mechanism of cocaine addiction.
