caspase-8-dependent cell death mode and cerebral ischemia/reperfusion injury
- VernacularTitle:caspase-8依赖的细胞死亡方式与脑缺血/再灌注损伤
- Author:
Yan-xi CHE
1
;
Xiu-ju LUO
;
Jun PENG
Author Information
- Publication Type:Journal Article
- Keywords: caspase-8; caspase-8 inhibitor; apoptosis; necrop-tosis; pyroptosis; cerebral ischemia/reperfusion
- From: Chinese Pharmacological Bulletin 2025;41(12):2240-2245
- CountryChina
- Language:Chinese
- Abstract: Caspase-8 is a cysteine-aspartate protease widely dis-tributed in cells.As a molecular"switch",caspase-8 is involved in the regulation of various modes of cell death,including apopto-sis,necroptosis and pyroptosis.During cerebral ischemia/reper-fusion,caspase-8 activation is one of the key factors inducing neuronal cell death.Currently there are both specific inhibitors of caspase-8,such as Z-IETD-FMK and Ac-IETD-CHO,as well as a variety of pan-caspase inhibitors,such as z-VAD,Q-VD-OPH,and enricosan.Both animal and cellular experiments have demonstrated that all of these inhibitors attenuate cerebral ische-mia/reperfusion injury,an effect that involves inhibition of caspase-8 activity and reduction of neuronal apoptosis.Clinical-ly,certain drugs for ischemic stroke reduce plasma caspase-8 ac-tivity,suggesting that caspase-8 may be a biomarker for the diag-nosis and prognosis of ischemic stroke.Finding and developing clinically valuable inhibitors around caspase-8 is expected to provide new ideas for new drug development in ischemic stroke.
