Mechanisms and intervention strategies of aging based on epigenetics
10.12360/CPB202505059
- VernacularTitle:基于表观遗传学探讨衰老的发生机制和干预策略
- Author:
Li-yuan ZHANG
1
;
Hao-nan SHI
;
Wen-feng ZHANG
;
Ming-qian ZHANG
;
Zi-yang ZHAO
;
Zhen-zhen CHENG
;
Ti ZHANG
;
Zhen-teng YAN
;
Jian-ning SUN
;
Shi-fen DONG
Author Information
1. 北京中医药大学中药学院,北京 102488
- Publication Type:Journal Article
- Keywords:
epigenetic regulation;
aging;
DNA methylation;
histone modification;
RNA modification;
three-dimensional ge-nome architecture;
entropy change
- From:
Chinese Pharmacological Bulletin
2025;41(12):2230-2235
- CountryChina
- Language:Chinese
-
Abstract:
Aging is comprehensively influenced by multiple fac-tors such as internal genes,cellular metabolism,external envi-ronment,and lifestyle habits.Among them,epigenetic regula-tion plays a core role.Epigenetic modifications,including DNA methylation,histone modification,heterochromatin remodeling,and non-coding RNA regulation,act in concert with the three-di-mensional genome architecture to precisely regulate gene expres-sion.This review elaborates on the factors influencing epigenetic regulation,as well as the mechanisms of how epigenetics affects the occurrence of organismal aging and the corresponding inter-vention strategies,providing relevant insights for uncovering the mechanisms of aging and preventing/treating aging-related disea-ses.
