Research advances in mitochondrial inflammation-mediated damage in central nervous system degenerative disorders
- VernacularTitle:中枢神经系统退行性病变中线粒体炎症损伤的研究进展
- Author:
Shu-qin LI
1
;
Sha-sha LIU
;
Qian YAN
;
Han-long WANG
;
Yang SUN
;
Yan-ting HUANG
;
Hao-jie ZHANG
;
Jin-ping LIANG
;
Shi-feng CHU
;
Yan-tao YANG
;
Qi-di AI
;
Nai-hong CHEN
Author Information
- Publication Type:Journal Article
- Keywords: central nervous system degenerative disorders; neurodegenerative diseases; mitochondrial inflammation; mito-chondrial DNA; reactive oxygen species; mitochondria-associat-ed endoplasmic reticulum membranes
- From: Chinese Pharmacological Bulletin 2025;41(12):2218-2225
- CountryChina
- Language:Chinese
- Abstract: Central nervous system(CNS)degenerative disorders refer to a spectrum of pathological alterations triggered by struc-tural damage to cerebral neural tissues,clinically manifested as diverse neurological dysfunction syndromes,including multiple sclerosis(MS),neurodegenerative diseases(NDs),and ische-mic stroke.The hallmark pathological features of these disorders involve irreversible neuronal damage and decompensation of functional neural networks,ultimately leading to progressive neurological deficits.Notably,with the accelerating global popu-lation aging,the incidence of these diseases has surged signifi-cantly.According to WHO statistics,they now rank among the top three global causes of disability and mortality.Current re-search has confirmed that the pathogenesis of CNS degenerative disorders exhibits high heterogeneity,encompassing multifaceted pathophysiological processes such as genetic predisposition,oxi-dative stress,protein misfolding,and metabolic dysregulation.This intricate pathogenic network not only complicates clinical differential diagnosis but also poses substantial challenges to the development of precision therapeutic strategies.Importantly,re-cent studies have revealed that mitochondrial homeostasis disrup-tion-induced inflammatory cascades(termed mitochondrial in-flammation)play a pivotal regulatory role in neurodegenerative progression.Key molecular mechanisms include impaired mito-phagy,aberrant mitochondrial DNA(mtDNA)release and NL-RP3 inflammasome activation.This review systematically deci-phers the molecular regulatory network of mitochondrial inflam-mation,with a focus on its biological effects in critical pathologi-cal events such as blood-brain barrier disruption,microglial hy-peractivation and neuronal apoptosis.The overarching aim is to provide a theoretical foundation for developing innovative thera-peutic strategies targeting mitochondrial homeostasis restoration.
