Research progress on sensitivity and resistance of antibiotics to plague

VernacularTitle:抗生素治疗鼠疫的敏感性和耐药性研究进展
Author: Xuan JIANG ¹ ; Daqin XU ; Dingsheng WANG ; Limin GUO ; Jinxiao XI
Author Information

1. 甘肃中医药大学公共卫生学院，兰州　730000
Publication Type:Journal Article
Keywords: Plague; Drug tolerance; Antibiotic susceptibility
From: Chinese Journal of Endemiology 2025;44(1):82-86
CountryChina
Language:Chinese
Abstract: The discovery of streptomycin in 1943 marked a new era in plague treatment. Over the subsequent eight decades, significant advances have been made through the implementation of various antibiotics, both as monotherapy and in combination regimens. These treatments have included aminoglycosides (such as streptomycin and gentamicin), tetracyclines, sulfonamides, chloramphenicol, quinolones, and beta-lactams, which have dramatically cut down the death rate from plague infections. However, due to bacterial adaptation mechanisms, Yersinia pestis can develop diminished sensitivity or resistance to certain antibiotics. This article examines the resistance mechanisms of Yersinia pestis and analyzes antimicrobial susceptibility patterns and resistance in plague treatment, aiming to provide scientific evidence for clinicians to understand the current status of traditional and new antibiotics in plague treatment and improve the treatment level of plague patients.