Anaphylaxis due to somatostatin and its analogue in a pediatric patient
10.3760/cma.j.issn.1008﹣5734.2019.04.016
- VernacularTitle:生长抑素及其类似物致儿童过敏反应
- Author:
Shengbo FANG
1
;
Xiaoying ZHANG
1
;
Yueyang LI
1
;
Wenrweui ZHANG
1
Author Information
1. 吉林大学第一医院药学部,长春,130021
- Publication Type:Journal Article
- Keywords:
Somatostatin;
Anaphylaxis;
Child;
Octreotide
- From:
Adverse Drug Reactions Journal
2019;21(4):303-304
- CountryChina
- Language:Chinese
-
Abstract:
A 12﹣year﹣old female pediatric patient received a continuous pumping of somatostatin 3 mg (added to 210 ml of 0. 9% sodium chloride injection)by an intravenous detaining needle on the back of her left hand and an IV infusion of pantoprazole sodium for injection 25 mg(added to 100 ml of 0. 9% sodium chloride injection)by an intravenous detaining needle on the back of her right hand at the same time for acute pancreatitis. About 5 minutes after the initiation of administration,cyanosis appeared on her both hands,her left hand was cold,and red rashes scattered on her left wrist and upper arm. It was considered as drug﹣induced anaphylaxis,and the drugs were discontinued immediately. About 40 minutes after drug withdrawal,her above symptoms relieved completely. Pantoprazole for injection was given again that day,and no allergic symptoms were observed. On day 2,a subcutaneous injection of 0. 1 g octreotide acetate injection( an analogue of somatostatin)was given. About 10 minutes later,the patient developed headache,nausea,and vomiting, which relieved spontaneously after 30 minutes. It was considered that the anaphylaxis was caused by somatostatin and its analogue octreotide.
