Effects of nasal gingerol gel on motion sickness
10.3760/cma.j.issn.1009-6906.2017.06.002
- VernacularTitle:姜酚鼻凝胶抗运动病效果研究
- Author:
Jie LUAN
1
;
Zhenzhen ZHANG
;
Xu FENG
;
Jingxian JIANG
;
Yingxin ZOU
;
Song CHEN
;
Zhiyong CHU
Author Information
1. 海军军医大学海军医学研究所, 上海,200433
- Publication Type:Journal Article
- Keywords:
Nasal gingerol gel;
Motion sickness;
Beagle dog;
SD rat
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2017;24(6):426-428
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of nasal gingerol gel on motion sickness .Methods The effects of nasal gingerol gel on motion sickness were evaluated by using the rat model of conditioned taste to observe changes in the amount of saccharine water intake , and also the Beagle dog model to observe the latent period of salivation and vomiting, before and after rotational stimulation.Results Before rotational stimulation, there were no significant differences in the amount of saccharine water intake in the rats of the groups . However, following rotational stimulation, the amount of saccharine water intake in the rats of the control group was obviously reduced, as compared with that before stimulation (P <0.01).Before drug treatment, all the Beagle dogs were susceptible to rotational stimulation , displaying early salivation and vomiting .However, after medication, the latent period of salivation and vomiting was all considerably delayed , as compared with the control group(P <0.05).The latent period of salivation of middle and high medication groups were extended to (17.89 ±8.42) min and (18.58 ±9.92) min, respectively.And the laent period of vomition of middle and high medication groups were extended to (25.50 ±12.78) min and (27.47 ±10.25) min.Conclusions Nasal gingerol gel showed certain protective effects against motion sickness .
