Effects of hyperbaric oxygen treatment timing on the prognosis of patients with acute cerebral infarction
10.3760/cma.j.issn.1009-6906.2017.05.002
- VernacularTitle:高压氧治疗时机对急性脑梗死患者预后的影响
- Author:
Lijuan WANG
1
;
Liuzhuang ZHAO
;
Yumei ZHAO
Author Information
1. 首都医科大学大兴医院神经内科, 北京,102600
- Publication Type:Journal Article
- Keywords:
Cerebral infarction;
Hyperbaric oxygen;
Treatment;
Therapeutic time window
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2017;24(5):343-347
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of different hyperbaric oxygen (HBO) treatment timing on the prognosis of the patients with acute cerebral infarction (ACI).Methods The patients with acute cerebral infarction that were conformed to the inclusion criteria were enrolled for the study,and were randomly divided into 3 groups,each consisting of 44 patients.The patients that received HBO therapy 1 to 6 days after the onset of ACI were designated as group A,the ones that were treated with HBO therapy 7 to 12 days after the onset of ACI were designated as group B,and the ones that didn 1 receive any HBO therapy were designated as group C.The patients in group A and B all received HBO therapy one session a day for a succession of 10 days.Both before and 10 days after treatment and 1 month after treatment,neural function defect and capacity of daily life activity were assessed by using National Institutes of Health Stroke Scale (NIHSS) and Barthel Index (BI).Therapeutic effects of HBO were compared between the groups.Results The NIHSS scores in group A [(2.11 ± 2.18) score,(0.93 ± 1.21) score] were significantly lower than those in group B [(3.43 ± 2.25) score,(1.70 ± 1.21) score] and group C [(4.68 ± 2.96) score,(2.55 ± 1.69) score],10 days and one month after treatment (P ＜ 0.05).The BI scores in group A were significantly higher than those in group B and group C,10 days and one month after treatment (P＜0.05).The NIHSS scores in group B 10 days and one month after treatment were significantly lower than those in group C (P ＜ 0.05).The BI scores in group B 10 days after treatment were significantly higher than those in group C (P ＜0.05).The BI scores in group B one month after treatment were higher than those in group C,but there was no significant difference,when comparisons were made between the 2 groups (P ＞ 0.05).Conclusions The therapeutic effects of HBO treatment 1 to 6 days and 7 to 12 days after the onset of ACI were all superior to that of the non-HBO group.However,the therapeutic effects of HBO treatment 1 to 6 days after the onset of ACI were obviously better.It could considerably improve the prognosis and life quality of the ACI patients.One to 6 days after onset is the effective HBO treatment time window for ACI.
