The expression of LAMB3 and ITGB4 in esophageal squamous cell carcinoma and their relationship with clinicopathological features
10.13315/j.cnki.cjcep.2025.10.006
- VernacularTitle:LAMB3和ITGB4在食管鳞状细胞癌中的表达及与其临床病理特征的关系
- Author:
Yali ZHAO
1
;
Sheng WU
;
Wei PENG
;
Wanxiang WANG
;
Haoran ZHANG
;
Zhenzhong FENG
;
Li MA
;
Xian WANG
Author Information
1. 安徽医科大学第二附属医院病理科,合肥 230601
- Publication Type:Journal Article
- Keywords:
esophageal neoplasms;
squamous cell carcinoma;
LAMB3;
ITGB4;
clinicopathological features;
progno-sis
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(10):1301-1307,1313
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the expression of LAMB3 and ITGB4 in esophageal squamous cell carcinoma(ESCC)and analyze their associations with clinicopathological features.Methods Bioinformatics was used to assess the expression of LAMB3 and ITGB4 in pan-cancer and ESCC.Immunohistochemistry was performed to evaluate their expression and distribution in ESCC tissues,and correlations clinicopathological features were analyzed.Follow-up data were collected to construct Kaplan-Meier survival curves,and Cox regression analysis was proformed to determine their prognostic significance.Results Bioinformatics analysis showed that LAMB3 and ITGB4 were highly expressed in ES-CC tissues(P＜0.001).Immunohistochemistry confirmed that both proteins were localized in the cytoplasm and membrane of tumor cells.High LAMB3 expression was significantly associated with poor differentiation(P＜0.001),lymph node metastasis(P=0.015),and T staging(P＜0.001).High ITGB4 expression was significantly correlated with poor differentiation(P=0.004)and advanced T staging(P=0.004).Cox regression analysis identified high ex-pression of LAMB3 and ITGB4 as independent prognostic factors for overall survival[HR=4.97(95％CI:2.73-9.02);HR=2.33(95％CI:1.36-3.99)].Conclusion LAMB3 and ITGB4 are highly expressed in ESCC.High LAMB3 expression is associated with tumor differentiation,lymph node metastasis,and T staging,while high ITGB4 expression is correlated with tumor differentiation and T staging.Patients with high expression of LAMB3 or ITGB4 have poorer overall survival,suggesting that these proteins may serve as prognostic biomarkers for unfavorable outcome in ESCC.
