Correlation between serum PLVAP levels and metabolism-related fatty liver disease in patients with type 2 diabetes mellitus
10.3969/j.issn.1006-6187.2024.12.001
- VernacularTitle:2型糖尿病患者血清质膜膜泡关联蛋白水平与代谢相关脂肪性肝病相关性的研究
- Author:
Rongrong WANG
1
;
Yuhui WANG
;
Tonghan YAO
;
Jing LIU
;
Simeng DAI
;
Xinying CHANG
;
Jing YU
;
Jumei CHOU
;
Qi ZHANG
Author Information
1. 730000 兰州,甘肃中医药大学第一临床医学院
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Metabolism-associated fatty liver disease;
Plasma membrane vesicle-associated protein;
Iectin-like oxidized low-denisty lipoprotein receptor-1
- From:
Chinese Journal of Diabetes
2024;32(12):881-885
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between serum plasma membrane vesicle-associated protein (PLVAP) levels and metabolism-associated fatty liver disease (MAFLD) in patients with T2DM. Methods Atotal of 255 patients with type 2 diabetes mellitus (T2DM) went to Gansu Provincial Hospital from September 2023 to March 2024 were selected in this study,and were divided into T2DM alone group (n=141) and the T2DM combined with MAFLD group (n=114) according to whether they were combined with MAFLD or not.Spearman correlation analysis was used to analyze the correlation between serum PLVAP and other indexes,multiple linear regression analysis was used to analyze the influencing factors of serum PLVAP,and Logistic regression analysis was used to analyze the influencing factors of MAFLD in T2DM patients. The early diagnostic value of serum PLVAP on MAFLD in patients with T2DM by analyzing the receiver's operating characteristics (ROC) curve. Results Compared with the MAFLD group,BMI,WC,FPG,C-P,HOMA-IR,TG,AST,ALT,GGT,hepatic steatosis index (HSI) and phytohaemagglutinin-like oxidized low-density lipoprotein receptor 1 (LOX-1) were decreased in the T2DM group (P<0.05).DM duration,HDL-C,AST/ALT and PLVAP were elevated (P<0.05). Spearman correlation analysis showed that PLVAP was positively correlated with AST/ALT (P<0.05) and negatively correlated with WC,DBP,C-P,ALT,GGT and HSI (P<0.05). Multiple linear regression analysis showed that WC was an influencing factor for PLVAP.Logistic regression analysis showed that DM duration,WC,TG,PLVAP,LOX-1 were influencing factors for MAFLD. Analysis of the subjects' work characteristics (ROC) curve showed that the area under the ROC curve was 0.785,with a sensitivity of 81.6％ and a specificity of 67.4％. Conclusions Reduced PLVAP is a risk factor for comorbid MAFLD in patients with T2DM and is important for predicting the co-existence of MAFLD in patients with T2DM.
